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Ivermectin acts on chloride channels and has documented neurotoxic effects in animals and occasional serious neurologic events in humans at therapeutic and higher doses.
Loss-of-function variants in the that abolish (P‑gp) efflux markedly increase , best documented as a 4‑bp deletion in herding‑breed dogs and as rare nonsense mutations in humans . Drugs that inhibit P...
Ivermectin is lipophilic, highly protein‑bound, and displays a human plasma half‑life around 18 hours with enterohepatic recycling and adipose accumulation that can prolong exposure . The drug’s acces...
P‑glycoprotein (P‑gp, ABCB1/MDR1) at the blood–brain barrier is the primary efflux transporter that prevents ivermectin from accumulating in the central nervous system by actively pumping the drug bac...
Taking ivermectin formulated for horses—commonly sold as “horse paste”—carries real and documented short-term risks in humans and poses plausible long-term harms primarily by way of toxicity from over...