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LDL Lowering and ASCVD Event Reduction

The relationship between lowering LDL cholesterol levels and reducing the risk of major vascular events, with evidence supporting more intensive LDL suppression.

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Jan 25, 2026
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What are the recommended nonstatin therapies and LDL-C thresholds for adding them in the 2025 guideline?

The and related lipid-guideline updates move decisively toward earlier and broader use of nonstatin lipid-lowering therapies, lowering thresholds for intensification into the mid-50s mg/dL for some hi...