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Index/Topics/Lecanemab and Donanemab Efficacy

Lecanemab and Donanemab Efficacy

The efficacy and safety of lecanemab and donanemab in slowing cognitive decline in patients with Alzheimer's disease.

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3 results
Jan 14, 2026
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How do anti‑amyloid antibodies like lecanemab and donanemab differ in trial design, efficacy and safety outcomes for early AD?

Lecanemab and donanemab are two recently approved anti‑amyloid monoclonal antibodies tested in large, randomized trials in early Alzheimer’s disease that both produced substantial amyloid PET clearanc...

Jan 14, 2026

What are the long‑term extension and real‑world safety/efficacy data available so far for lecanemab and donanemab?

Two monoclonal antibodies—lecanemab and donanemab—have randomized-trial evidence of modest slowing of cognitive decline at 18 months and emerging longer-term data for lecanemab suggesting continued, s...

Jan 7, 2026

How clinically meaningful are the cognitive changes seen with lecanemab and donanemab in real‑world patients?

The randomized trials of lecanemab and donanemab showed statistically significant slowing of cognitive and functional decline over 18 months, but the absolute differences were small versus placebo and...

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