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Index/Topics/Lecanemab and Donanemab Trials

Lecanemab and Donanemab Trials

The pivotal trials of lecanemab and donanemab demonstrating amyloid plaque lowering and modest slowing of clinical decline

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Feb 1, 2026

How do baseline tau PET levels modify the effect of amyloid‑lowering antibodies on clinical decline?

Baseline measured by strongly modifies how much clinical benefit patients derive from amyloid‑lowering antibodies: lower neocortical tau at baseline associates with larger slowing of cognitive decline...

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