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Index/Topics/Lecanemab clinical trial

Lecanemab clinical trial

Lecanemab’s amyloid substudy and its effects on amyloid levels and clinical decline

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Jan 22, 2026

What Centiloid changes after anti‑amyloid therapy have been observed in trials, and how do they map to clinical benefit?

of anti‑amyloid monoclonal antibodies have repeatedly shown large Centiloid (CL) reductions—often taking mean group values from high baseline CL into ranges below the conventional positivity threshold...

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