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Loa loa infection and its relation to ivermectin treatment
most commonly produces gastrointestinal upset and a spectrum of neurologic effects ranging from dizziness and somnolence to confusion, ataxia, seizures, coma and, rarely, death; serious encephalopathy...
Clinical evidence that produces adverse events when taken with is limited but plausible: published human case series and post‑marketing reports identify serious neurological events occurring with conc...
Clinical and mechanistic evidence points to two principal pathways that can increase central nervous system (CNS) exposure to ivermectin: impairment of P‑glycoprotein (P‑gp, MDR‑1) efflux at the blood...
Ivermectin should be avoided by people with known hypersensitivity to the drug, by pregnant women unless benefits clearly outweigh risks, by those using veterinary formulations, and by people with spe...
Loa loa co‑infection raises the risk of encephalopathy after ivermectin principally when patients harbour very high peripheral microfilarial densities; rapid killing or redistribution of those microfi...