Index/Topics/Meta-Analyses

Meta-Analyses

The use of meta-analyses in clinical trials, including the advantages and limitations of individual participant data (IPD) meta-analyses and aggregate-data meta-analyses.

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10 results
Jan 12, 2026
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How do GLP‑1 drugs affect cardiovascular risk markers while on treatment versus after discontinuation?

GLP‑1 receptor agonists improve multiple cardiovascular risk markers—weight, glycaemic control, blood pressure, lipids and inflammatory biomarkers—and reduce major adverse cardiovascular events (MACE)...

Feb 6, 2026

How do clinical study reports published by regulators differ from raw individual participant‑level datasets, and why does that matter for independent reanalysis?

and regulator summaries are curated, document-level narratives and aggregated analyses of trials, while individual participant data (IPD) are the raw, participant‑level records that underlie those sum...

Feb 5, 2026

What does the clinical trial evidence say about vacuum therapy versus oral ED medications?

The material provided contains clinical and device-focused reporting on vacuum-assisted therapies in , and , but contains no clinical-trial evidence directly comparing (ED); therefore no evidence-base...

Jan 20, 2026

How reliable are penis size measurement studies?

Penis-size research produces usable population estimates but is plagued by methodological pitfalls that reduce reliability: self-reporting inflates averages, measurement technique and observer bias ca...

Jan 17, 2026

What large, registered randomized trials of Bacopa monnieri are planned or ongoing, and where can their protocols and registries be accessed?

There are several registered randomized trials of Bacopa monnieri that have completed or reported results and a few recent registrations accessible via public registries, but no single large, definiti...

Jan 13, 2026

Do randomized trials show capsinoids improve weight loss or metabolic outcomes in obese, BAT‑negative, or older adults?

Randomized trials and meta-analyses show that capsinoids and related capsaicinoids can produce modest increases in energy expenditure and, in some trials, small reductions in abdominal fat or body wei...

Jan 12, 2026

What randomized clinical trials exist for cinnamon, chromium, and ginseng in type 2 diabetes management?

Randomized clinical trials (RCTs) testing cinnamon, chromium, and ginseng for type 2 diabetes (T2D) are numerous but heterogeneous: cinnamon has been evaluated in many small RCTs and several meta-anal...

Jan 10, 2026

Which countries’ penis size estimates are based on sample sizes under 100, and how does small N affect ranking stability?

Public country-by-country penis-size rankings rest on a patchwork of clinical studies, self-reports and meta-analyses, many of which draw from small, localized samples; the provided sources do not lis...

Jan 9, 2026

How do catechin doses and caffeine amounts modify green tea extract effects on 24‑hour energy expenditure in humans?

Controlled respiratory‑chamber trials and meta‑analyses show that green tea extracts containing both catechins (especially EGCG) and caffeine produce small but measurable increases in 24‑hour energy e...

Jan 5, 2026

How do outcomes of endoscopic lumbar decompression compare to open decompression in randomized studies?

Randomized trials and pooled analyses show that endoscopic lumbar decompression delivers broadly comparable patient-reported functional outcomes to microscopic/open decompression but—with important ca...