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Index/Topics/Metabolic Acidosis

Metabolic Acidosis

The relationship between metabolic acidosis, vascular endothelial function, and the potential benefits of oral bicarbonate therapy in patients with CKD.

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Jan 10, 2026

What human clinical trials have tested oral sodium bicarbonate for endothelial function or blood flow?

Three types of human studies have tested oral sodium bicarbonate with endpoints tied to endothelial function or blood flow: small randomized trials (including a 2018 pilot crossover trial), short sing...

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