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Index/Topics/Methylene Blue

Methylene Blue

Methylene blue (methylthioninium chloride, MTC) as a control in trials

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Jan 29, 2026

What randomized clinical trial evidence supports efficacy of hydromethylthionine (HMTM) at 8–16 mg/day versus placebo in Alzheimer's disease?

(HMTM, formerly LMTM) has produced mixed randomized trial evidence: large Phase III programs failed to show a simple dose‑response signal when high doses (150–250 mg/day) were compared with an 8 mg/da...

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