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Index/Topics/MRI Surveillance

MRI Surveillance

The use of MRI scans to monitor patients treated with lecanemab and donanemab for signs of ARIA.

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Jan 15, 2026
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How does APOE‑ε4 carrier status change the management and MRI surveillance schedule for patients on lecanemab or donanemab?

APOE‑ε4 carrier status meaningfully raises the risk of amyloid‑related imaging abnormalities (ARIA) with both lecanemab and donanemab, and that elevated risk has been translated into mandatory APOE ge...

Jan 12, 2026
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What are the specific risks and monitoring requirements for patients receiving lecanemab or donanemab?

Two monoclonal antibodies—lecanemab (Leqembi) and donanemab (Kisunla)—offer modest slowing of early Alzheimer’s symptoms but carry specific, sometimes serious safety risks that require structured moni...