Nicotine Gum Dosage

How do typical nicotine gum dosing regimens (2 mg vs 4 mg per piece) translate into mg/kg/day for adults compared with doses used in rodent studies?

Two commercially available nicotine gums deliver either 2 mg or 4 mg of nicotine per piece, and trials and guidelines describe usage patterns ranging from “as needed” every 1–2 hours to regimented hou...