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NIH guidance on clinical trials

Guidance from the National Institutes of Health on later-phase trials

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Jan 24, 2026
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How do Phase 1, Phase 2 and Phase 3 oncology trials differ in what they can prove about safety and efficacy?

occupy distinct roles in the evidence ladder: Phase 1 primarily establishes safety, tolerability and a recommended dose; Phase 2 tests for signs of anti‑tumor activity and refines safety in the target...

Jan 16, 2026

How do parent-mediated interventions change the dose–response relationship for early therapies in toddlers with ASD?

Parent‑mediated interventions (PMIs) alter the dose–response curve for early ASD therapies by effectively multiplying the child’s therapeutic exposure outside clinic hours—turning training hours for p...