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Opioid Antagonists for Dissociation

The potential of opioid antagonists like naloxone and naltrexone in treating depersonalization and dissociative symptoms.

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Jan 31, 2026
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Which pharmacologic agents have RCT evidence for depersonalization or dissociative symptoms and how do those findings apply to DID?

Several randomized controlled trials (RCTs) have tested medications for depersonalization and dissociative symptoms, with modest positive findings for the SSRI and early signal for opioid antagonists ...