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Index/Topics/Osteoporosis Risk

Osteoporosis Risk

The potential long-term risk of osteoporosis associated with puberty blockers

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Jan 24, 2026
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How do puberty blockers affect bone density and are effects reversible in adolescents?

(GnRH agonists) commonly slow or halt the normal accrual of bone mineral density (BMD) during adolescence, with studies showing flatlined or decreased BMD—especially at the lumbar spine—while on treat...

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