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OTC Fat Burner Supplements Efficacy

The efficacy and safety of over-the-counter fat burner supplements, including ingredients like Irvingia/IGOB131, berberine, caffeine, and green-tea catechins, as compared to prescription drugs and lifestyle interventions.

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Jan 11, 2026

What clinical evidence supports the ingredients commonly used in Laellium (berberine, green tea extract, ACV) for weight loss?

Clinical trials and multiple meta-analyses show that berberine produces modest but statistically significant reductions in body weight, BMI and waist circumference and affects metabolic markers, green...

Jan 5, 2026

What clinical trials exist for over‑the‑counter weight‑loss supplements marketed as 'fat burners'?

Over‑the‑counter (“OTC”) fat‑burner supplements have been the subject of many small, ingredient‑specific clinical trials—some showing modest metabolic changes or small weight losses, but overall the e...