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P-glycoprotein's role in ivermectin neurotoxicity
No explicit pharmacovigilance case reports documenting confirmed drug–drug interactions between (antiemetics, growth factors, or antibiotics) are identified in the provided reporting; instead, the lit...
Suspected ivermectin neurotoxicity is managed primarily with supportive care, close neurologic monitoring, and targeted interventions guided by toxicology consultation because no proven clinical antid...
P‑glycoprotein (P‑gp, ABCB1/MDR1) at the blood–brain barrier is the primary efflux transporter that prevents ivermectin from accumulating in the central nervous system by actively pumping the drug bac...
Yes — evidence from laboratory studies, pharmacology reviews and post‑marketing case series shows a plausible and documented risk that ivermectin’s CNS effects and its interactions with drug‑transport...