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P-glycoprotein

P-glycoprotein's role in ivermectin neurotoxicity

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3 results
Jan 17, 2026
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What clinical management and monitoring protocols have been recommended for suspected ivermectin neurotoxicity, especially with potential drug–drug interactions?

Suspected ivermectin neurotoxicity is managed primarily with supportive care, close neurologic monitoring, and targeted interventions guided by toxicology consultation because no proven clinical antid...

Jan 9, 2026

How do P-glycoprotein and other efflux transporters affect ivermectin entry into the human brain?

P‑glycoprotein (P‑gp, ABCB1/MDR1) at the blood–brain barrier is the primary efflux transporter that prevents ivermectin from accumulating in the central nervous system by actively pumping the drug bac...

Jan 8, 2026

Can ivermectin increase risk of neurotoxicity when taken with other CNS depressants?

Yes — evidence from laboratory studies, pharmacology reviews and post‑marketing case series shows a plausible and documented risk that ivermectin’s CNS effects and its interactions with drug‑transport...