Index/Topics/P-glycoprotein

P-glycoprotein

The topic is about the biological pathway that explains why some overdoses produce severe neurologic injury.

Fact-Checks

5 results
Jan 22, 2026
Most Viewed

Are there documented pharmacovigilance case reports describing drug–drug interactions between ivermectin and specific oncology supportive medications (antiemetics, growth factors, or antibiotics)?

No explicit pharmacovigilance case reports documenting confirmed drug–drug interactions between (antiemetics, growth factors, or antibiotics) are identified in the provided reporting; instead, the lit...

Jan 17, 2026
Most Viewed

What clinical management and monitoring protocols have been recommended for suspected ivermectin neurotoxicity, especially with potential drug–drug interactions?

Suspected ivermectin neurotoxicity is managed primarily with supportive care, close neurologic monitoring, and targeted interventions guided by toxicology consultation because no proven clinical antid...

Feb 7, 2026

Are there long-term effects from ivermectin overdose?

Short answer: yes—an overdose of can cause serious acute neurological and systemic harm, and there are credible reports and mechanistic reasons to expect some individuals may experience persistent or ...

Jan 9, 2026

How do P-glycoprotein and other efflux transporters affect ivermectin entry into the human brain?

P‑glycoprotein (P‑gp, ABCB1/MDR1) at the blood–brain barrier is the primary efflux transporter that prevents ivermectin from accumulating in the central nervous system by actively pumping the drug bac...

Jan 8, 2026

Can ivermectin increase risk of neurotoxicity when taken with other CNS depressants?

Yes — evidence from laboratory studies, pharmacology reviews and post‑marketing case series shows a plausible and documented risk that ivermectin’s CNS effects and its interactions with drug‑transport...