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Interactions with P-glycoprotein can increase the risk of neurologic adverse events in patients taking ivermectin.
Serious neurologic adverse events (encephalopathy, seizures, coma, persistent coma, ataxia) after ivermectin are uncommon but documented, and risk clusters around particular parasitic coinfections (no...
Ivermectin is lipophilic, highly protein‑bound, and displays a human plasma half‑life around 18 hours with enterohepatic recycling and adipose accumulation that can prolong exposure . The drug’s acces...
Repeated-dose oral ivermectin can interact with a range of medications commonly taken by older adults, most notably blood thinners such as warfarin, strong CYP3A4 inhibitors (for example ketoconazole ...