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Index/Topics/PDE-5 Inhibitors and Hearing Loss

PDE-5 Inhibitors and Hearing Loss

The potential link between PDE-5 inhibitors, such as sildenafil, and sudden sensorineural hearing loss

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Jan 18, 2026

Can long-term use of sildenafil impact cardiovascular health or cause hearing loss?

Long-term sildenafil use carries known cardiovascular cautions—most critically dangerous interactions (for example with nitrates) and rare reports of serious cardiac events—while population and pharma...

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