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Index/Topics/PDE5 Agents

PDE5 Agents

Development of topical/transdermal delivery of PDE5 agents for erectile dysfunction treatment

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Jan 31, 2026

How effective are topical ED creams compared with prescription PDE‑5 inhibitors in clinical trials?

—most robustly studied in the form of alprostadil formulations—have demonstrated clinically meaningful benefit in randomized trials and real‑world use, particularly for men who cannot take ; however, ...

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