Index/Topics/PDE5 inhibitors

PDE5 inhibitors

A class of drugs used to treat erectile dysfunction

Fact-Checks

17 results
Jan 12, 2026
Most Viewed

Does baking soda and salt make your cock hard

The short answer: there is no reliable evidence that drinking or applying a mix of baking soda (sodium bicarbonate) and salt will acutely produce an erection or “make your cock hard” . The idea circul...

Jan 23, 2026
Most Viewed

How can trans women preserve their penis size?

during is achievable in some cases but rests on a mix of clinical strategies, off-label approaches, and sparse data; most guidance is extrapolated from small studies, cis-male medicine, clinician expe...

Jan 22, 2026
Most Viewed

What are the proven medical treatments for erectile dysfunction and how do they work?

is treated with a stepped approach: lifestyle and addressing underlying disease, first-line oral phosphodiesterase type 5 inhibitors (PDE5-Is), then local mechanical or injectable therapies, and final...

Jan 14, 2026

Can baking soda harm ones penis?

Baking soda (sodium bicarbonate) is not a proven treatment for erectile dysfunction and can cause harm if misused; ingesting it delivers a high sodium load that can raise blood pressure and trigger me...

Jan 29, 2026

How does Prelox (Pycnogenol + L‑arginine) compare to PDE5 inhibitors like sildenafil in randomized trials?

(a proprietary combination of L‑arginine aspartate and ®) has demonstrated statistically significant improvements in versus placebo in randomized trials, with effects reported to accrue over weeks to ...

Jan 16, 2026

How to improve erections on adhd meds

Erectile problems while taking ADHD medication are a recognized and treatable issue: stimulant drugs (methylphenidate, amphetamines) are associated with higher rates of erectile dysfunction and altere...

Feb 1, 2026

What documented side effects and long‑term safety data exist for common prescription male‑performance medications compared to herbal supplements?

( like sildenafil, tadalafil and vardenafil) have well‑documented side‑effect profiles and decades of safety data from clinical trials and pharmacovigilance, but they carry known cardiovascular and dr...

Jan 19, 2026

Which patient subgroups (severity, comorbidity, PDE5i responders) show the greatest randomized‑trial benefit from LiSWT?

There are no LiSWT–specific randomized‑trial subgroup results in the provided reporting, so any statement about which patients definitively derive the greatest randomized‑trial benefit from low‑intens...

Jan 13, 2026

What are the safety risks and potential side effects of ingesting baking soda compared with PDE5 inhibitors like sildenafil?

Viral claims that ingesting baking soda delivers rapid relief for erectile dysfunction lack credible clinical evidence and can cause real harm such as metabolic alkalosis, high sodium load, and worsen...

Feb 6, 2026

Can erectile dysfunction treatments reliably shorten the refractory period in older men according to randomized trials?

Randomized-trial evidence does not establish that erectile dysfunction () treatments reliably shorten the post‑ejaculatory refractory period in older men; the clearest randomized signal comes from a s...

Feb 3, 2026

How do SSRIs and other common medications affect male orgasm and ejaculation?

Selective serotonin reuptake inhibitors ( commonly delay ejaculation, blunt orgasm intensity or cause anorgasmia in many men, and those effects can sometimes persist after stopping the drug (post‑SSRI...

Jan 18, 2026

What randomized trials compare vacuum erection devices, PDE5 inhibitors, and intracavernosal injections for penile rehabilitation after radical prostatectomy?

Randomized trials exist for each modality—PDE5 inhibitors (PDE5i), vacuum erection devices (VED), and intracavernosal injections (ICI)—and several randomized studies and systematic reviews report bene...

Jan 13, 2026

Which medications can improve orgasmic function post-penile-implant and what are their risks?

Penile implants generally do not impair the ability to orgasm or ejaculate, and in some cases can restore orgasmic function when the cause was psychogenic rather than neurologic or systemic disease . ...

Jan 12, 2026

What evidence exists for the safety and efficacy of common ingredients claimed in male enhancement supplements?

Clinical evidence for most over‑the‑counter “male enhancement” supplement ingredients is weak and inconsistent: a few botanical or nutraceutical components (ginseng, L‑arginine, pycnogenol, flavonoids...

Jan 10, 2026

Are lifestyle changes and FDA-approved medications for ED more effective than alternatives promoted on TV?

Lifestyle changes and FDA‑approved erectile dysfunction (ED) medications are, on balance, more reliably effective and safer than the panoply of “natural” or TV‑promoted alternatives; FDA‑approved PDE5...

Jan 7, 2026

What are the documented health harms and drug interactions from consuming supplements adulterated with PDE‑5 inhibitors?

Supplements marketed as “herbal” or “natural” for sexual performance are frequently found to contain undeclared prescription PDE‑5 inhibitors (like sildenafil, tadalafil, vardenafil) or unapproved ana...

Jan 6, 2026

What does clinical research show about L‑arginine and zinc for erectile dysfunction?

Clinical trials and meta-analyses show that oral L‑arginine—an amino acid precursor to nitric oxide—has produced modest but statistically significant improvements in erectile function in men with mild...