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Index/Topics/PDE5 Inhibitors and Alternative Treatments

PDE5 Inhibitors and Alternative Treatments

PDE5 inhibitors as a treatment option for erectile dysfunction and penis pumps as a non-pharmacologic alternative.

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3 results
Jan 18, 2026
Most Viewed

How effective are pumps compared with PDE5 inhibitors and penile injections for long‑term erectile function restoration?

PDE5 inhibitors are the established first‑line therapy for ED with roughly 60–70% initial response and substantial evidence that chronic/daily use can help preserve or improve long‑term erectile funct...

Jan 19, 2026

What trial designs best test whether prior PDE5 inhibitor response modifies benefit from new ED therapies?

To test whether prior response to PDE5 inhibitors modifies benefit from a new erectile dysfunction (ED) therapy, the most reliable approaches are prospective randomized designs that stratify or random...

Jan 12, 2026

How do vacuum erection devices compare to medications and surgery for chronic ED over years?

Vacuum erection devices (VEDs) are a durable, non‑invasive option that reliably produces erections mechanically and can be a long‑term alternative or adjunct to oral PDE5 inhibitors and to definitive ...

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