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PDE5 Inhibitors and CYP3A4 Inhibitors Interaction

The interaction between PDE5 inhibitors and CYP3A4 inhibitors, including the effects on plasma levels and the necessary dose adjustments.

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2 results
Feb 2, 2026

How do prescription nitrates like nitroglycerin interact with common ED drugs (PDE‑5 inhibitors) and OTC supplements?

Prescription organic nitrates such as nitroglycerin interact dangerously with phosphodiesterase‑5 (PDE5) inhibitors used for because both drug classes increase cyclic GMP (cGMP) in vascular smooth mus...

Jan 28, 2026

Which CYP3A4 inhibitors require dose adjustment or avoidance of specific PDE5 inhibitors?

Potent and moderate —including azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (erythromycin, clarithromycin), (ritonavir, saquinavir, amprenavir, fosamprenavir and others), cert...