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PDE5 Inhibitors and Grapefruit Juice Interaction

The interaction between PDE5 inhibitors and grapefruit juice, including the effects on drug metabolism and the risk of adverse events.

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2 results
Feb 3, 2026

How do food and alcohol affect the onset and effectiveness of different PDE5 inhibitors?

Alcohol commonly amplifies the blood-pressure–lowering and vasodilatory effects of PDE5 inhibitors, raising the risk of dizziness, fainting and other adverse events, while certain foods—most notably —...

Jan 28, 2026

Which CYP3A4 inhibitors require dose adjustment or avoidance of specific PDE5 inhibitors?

Potent and moderate —including azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (erythromycin, clarithromycin), (ritonavir, saquinavir, amprenavir, fosamprenavir and others), cert...