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PDE5 inhibitors and NAION

The relationship between phosphodiesterase-5 (PDE5) inhibitors and non-arteritic anterior ischemic optic neuropathy (NAION), including the existence of a causal link.

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Jan 14, 2026

What is the evidence linking PDE5 inhibitors to non‑arteritic anterior ischemic optic neuropathy (NAION)?

The published evidence linking phosphodiesterase‑5 (PDE5) inhibitors (sildenafil, tadalafil, vardenafil) to non‑arteritic anterior ischemic optic neuropathy (NAION) is mixed: epidemiologic meta‑analys...