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PDE5 Inhibitors and Nitrates Interaction

The established contraindication of combining PDE5 inhibitors with nitrates due to the risk of sudden and severe hypotension.

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Jan 11, 2026
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How do l-arginine and l-citrulline interact with common ED medications like sildenafil or nitrates?

L-arginine and L-citrulline raise nitric oxide (NO) availability by serving as substrates in the NO pathway, which can modestly lower blood pressure and improve erectile function on their own; phospho...