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PDE5 Inhibitors Comparison

Comparison of PDE5 inhibitors for treating erectile dysfunction, including their pharmacokinetics, tolerability, and safety

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Feb 2, 2026

How do PDE5 inhibitors differ in onset and duration of action and which is best for on‑demand use?

differ primarily in pharmacokinetics—how quickly they reach effective blood levels (onset) and how long they remain active (duration)—and those differences drive which drug is optimal for “on‑demand” ...

Jan 14, 2026

Are there patient characteristics that predict better tolerability of one PDE5 inhibitor over another?

Yes — some patient characteristics can guide which PDE5 inhibitor is likely to be better tolerated, but the signal is modest: pharmacokinetic differences (half‑life, food interactions), cardiovascular...