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Index/Topics/PEGylated Lipids

PEGylated Lipids

Lipids that have been modified with polyethylene glycol (PEG) to improve their stability and reduce immune responses.

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Jan 24, 2026

What are the functions and typical safety profiles of the lipid nanoparticle components (e.g., SM-102, PEG) used in mRNA vaccines?

are engineered ensembles of four lipid types—an ionizable cationic lipid (e.g., SM-102), a neutral phospholipid (e.g., DSPC), cholesterol, and a PEGylated lipid—that together protect mRNA, mediate cel...

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