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Index/Topics/PFAS Dermal Uptake

PFAS Dermal Uptake

The primary topic is about the dermal uptake of PFAS, including the comparison of in vitro and in vivo studies, and the factors that influence the absorption of PFAS in human skin.

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Jan 11, 2026

How do dermal absorption percentages from 3D skin models compare with in vivo human dermal studies for PFOA and short‑chain PFAS?

In vitro 3D human skin equivalent models report substantially higher dermal uptake fractions for many PFAS—including a PFOA permeation of ~13.5% with ~38% retained in skin and much larger fractions fo...

Jan 11, 2026

Which PFAS species have documented dermal absorption in 3D human skin models and what are their reported transfer rates?

A 2024 in vitro study using 3D human skin equivalent models tested 17 PFAS and found dermal uptake for most compounds: 15 of the 17 showed at least 5% systemic absorption under the study conditions (e...