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Index/Topics/P‑gp Inhibitors

P‑gp Inhibitors

Drugs that inhibit P‑gp can increase central nervous system exposure risk

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Feb 2, 2026

What specific drugs most commonly interact with ivermectin via CYP3A4 and how are those interactions managed?

is primarily metabolized by cytochrome P450 3A4 (CYP3A4), so drugs that strongly inhibit or induce CYP3A4 can change ivermectin exposure; in vitro and animal data identify several likely perpetrators,...

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