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The need for direct, comparative human pharmacokinetic studies to determine the differences in SAC and S1PC absorption, distribution, and elimination between Kyolic AGE and black garlic products.
Orally administered S‑allyl‑L‑cysteine (SAC) and S‑1‑propenyl‑L‑cysteine (S1PC) show high apparent oral availability in preclinical models and are measurable constituents of both aged garlic extract (...
Emergency departments should treat severe as a primarily supportive, symptom-driven emergency because there is no specific antidote and formal treatment guidelines are lacking; early airway, breathing...
Ivermectin’s pharmacokinetics are dominated by slow absorption, wide tissue distribution, low metabolic clearance and slow excretion, but those broad traits are heavily modulated by route and formulat...
Published human case reports do include numeric measurements of ivermectin in cerebrospinal fluid (CSF): at least one peer‑reviewed case reported a CSF ivermectin concentration of 0.14 ng/mL with an a...
Ivermectin’s pharmacokinetics are shaped by its high lipophilicity, producing clear differences between low‑body‑weight (including undernourished children) and obese subjects: obese individuals tend t...
A high‑fat meal can increase systemic exposure to oral ivermectin by improving solubilization and absorption of this lipophilic drug, but the magnitude of that effect is inconsistent across studies an...
Single oral doses of ivermectin produce a dose-proportional peak plasma concentration (Cmax) with a terminal half-life around 18–20 hours after typical human doses, while repeated or multi-day regimen...