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Index/Topics/Pharmacokinetics

Pharmacokinetics

The study of how ivermectin is absorbed, distributed, metabolized, and eliminated by the body, including its hepatic-centered elimination profile.

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4 results
Jan 19, 2026

How do preclinical ivermectin dosing levels in mice compare with human pharmacokinetic tolerability in oncology studies?

Preclinical mouse studies of ivermectin report effective antitumor activity across a wide dose range—commonly 0.5–10 mg/kg and in some reviews up to 40 mg/kg—with many experiments using ~3–10 mg/kg to...

Jan 15, 2026

How does ivermectin interact with liver or kidney function?

Ivermectin is extensively metabolized by the liver and is eliminated mainly via feces rather than the kidneys, which helps explain why clinically significant renal clearance is minimal . Human pharmac...

Jan 10, 2026

How do forensic toxicologists distinguish therapeutic, toxic, and lethal fentanyl concentrations in individual cases?

Forensic toxicologists do not rely on a single cut‑off number to label a fentanyl concentration “therapeutic,” “toxic,” or “lethal”; instead they combine measured concentrations with specimen type and...

Jan 8, 2026

How do veterinary ivermectin formulations differ in concentration and excipients from human prescriptions?

Veterinary ivermectin formulations differ from human prescriptions primarily in concentration, formulation type, and inactive ingredients: animal products are made as high‑strength injectables, pour‑o...

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