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Prescription Medicines for Weight Loss

Prescription medicines like GLP-1 and GLP-1/GIP agents are more effective for weight loss than over-the-counter supplements.

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Jan 21, 2026
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Which clinically tested medications are proven to help with weight loss and how do they compare to over‑the‑counter supplements?

Prescription medicines tested in randomized clinical trials — notably GLP‑1 and GLP‑1/GIP agents such as tirzepatide and semaglutide — produce the largest, most consistent weight loss signals (single‑...