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Prescription phosphodiesterase‑5 inhibitors (e.g., sildenafil) have large, consistent randomized trial evidence and predictable pharmacology
Sildenafil, tadalafil and vardenafil share a broadly similar adverse‑effect footprint — headaches, flushing, dyspepsia and nasal congestion are the common themes — but they differ in pharmacokinetics ...
There is no credible evidence in the collected reporting that baking soda (sodium bicarbonate) is an effective treatment for erectile dysfunction, and none of the sources reviewed document a direct ph...
L-arginine and L-citrulline raise nitric oxide (NO) availability by serving as substrates in the NO pathway, which can modestly lower blood pressure and improve erectile function on their own; phospho...
Long-term sildenafil use carries known cardiovascular cautions—most critically dangerous interactions (for example with nitrates) and rare reports of serious cardiac events—while population and pharma...
Penile prostheses mechanically restore rigidity for penetrative sex but do not re-create the neurovascular mechanisms that produce natural erections, and most guidelines and studies emphasize that imp...
Herbal remedies such as red ginseng, yohimbe/yohimbine and horny goat weed are widely marketed for erectile dysfunction (ED) and have some biological rationale and mixed clinical signals, but the clin...