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PSA doubling time

PSA doubling time measures how long it takes for prostate-specific antigen in the blood to double and is used after radical prostatectomy to stratify risk of metastasis and guide timing and intensity of salvage therapies.

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Jan 17, 2026
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How reliable are PSA doubling time calculations at very low PSA values and what standard methods reduce variability?

PSA doubling time (PSADT) at very low PSA levels is intrinsically noisy: measurement error, biological fluctuation and divergent calculation methods can change estimated PSADT enough to affect clinica...