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PSA Doubling Time Calculation

The calculation of PSA doubling time using the log-slope method and its implications for clinical practice and research.

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Jan 13, 2026
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How is PSA doubling time calculated in clinical practice and which formula is recommended?

PSA doubling time (PSADT) is calculated by fitting an exponential (log-linear) model to serial PSA values and using PSADT = ln divided by the slope of ln(PSA) versus time; this log‑slope method is the...