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PSA Surveillance

PSA surveillance after radical prostatectomy

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4 results
Jan 12, 2026
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What are guideline differences between NCCN, AUA, and EAU on post‑prostatectomy PSA surveillance and why?

Three major prostate‑cancer guideline bodies—NCCN, AUA, and EAU—agree on the central role of serial PSA after radical prostatectomy but diverge on measurement sensitivity, timing of intervention, imag...

Jan 18, 2026
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Can elevated PSA levels after prostate surgery indicate cancer recurrence?

Yes — a rise in prostate‑specific antigen (PSA) after radical prostatectomy is commonly the earliest laboratory sign that prostate cancer may have recurred, but interpretation depends on timing, magni...

Jan 17, 2026
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How reliable are PSA doubling time calculations at very low PSA values and what standard methods reduce variability?

PSA doubling time (PSADT) at very low PSA levels is intrinsically noisy: measurement error, biological fluctuation and divergent calculation methods can change estimated PSADT enough to affect clinica...

Jan 22, 2026

How should management (staging, systemic therapy, trials) change for patients with high‑grade prostate cancer and very low PSA?

(Grade Group 4–5 or Gleason ≥8) with a deceptively low serum PSA should trigger more aggressive staging and consideration of treatment intensification rather than reassurance; modern imaging (includin...