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The use of polyvinylpyrrolidone (PVP) and arabinogalactan (AG) as formulation excipients to improve ivermectin's solubility and absorption.
Single oral doses of ivermectin produce a dose-proportional peak plasma concentration (Cmax) with a terminal half-life around 18–20 hours after typical human doses, while repeated or multi-day regimen...
Formulating ivermectin with solubility enhancers such as polyvinylpyrrolidone (PVP) or arabinogalactan (AG) reliably increases apparent solubility and bioavailability and can permit lower effective do...
Polyvinylpyrrolidone (PVP) and arabinogalactan (AG) act as formulation excipients that increase ivermectin’s apparent solubility and modify absorption, and mechanochemical complexes containing these e...