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Recreational Use of PDE5 Inhibitors and Alcohol

The recreational use of PDE5 inhibitors and alcohol, including the risks of adverse events and the potential for misuse.

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Feb 3, 2026

How do food and alcohol affect the onset and effectiveness of different PDE5 inhibitors?

Alcohol commonly amplifies the blood-pressure–lowering and vasodilatory effects of PDE5 inhibitors, raising the risk of dizziness, fainting and other adverse events, while certain foods—most notably —...