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Sperm Recovery

The recovery of sperm production after stopping hormone therapy

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Jan 22, 2026
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What fertility impacts does gender-affirming HRT have and can fertility be restored after stopping treatment?

Gender-affirming hormone therapy () commonly suppresses gametogenesis: estrogen plus anti-androgens reduces spermatogenesis in transfeminine people and testosterone suppresses ovulation in transmascul...

Jan 15, 2026

What are typical timelines for sperm production suppression and fertility recovery after starting estrogen and anti-androgens?

Estrogen plus anti-androgens suppress sperm production by shutting down the hypothalamic–pituitary–gonadal axis within weeks, with many patients developing severe oligozoospermia or azoospermia by abo...