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Index/Topics/SSRI-Induced Sexual Dysfunction

SSRI-Induced Sexual Dysfunction

SSRIs, especially paroxetine, are associated with sexual dysfunction, including decreased libido and orgasmic disturbances.

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Jan 9, 2026

What are the comparative rates of sexual dysfunction between individual SSRIs, SNRIs, bupropion and mirtazapine in randomized trials?

Randomized trials and pooled analyses consistently show that serotonergic antidepressants — SSRIs and SNRIs — carry substantially higher rates of treatment-emergent sexual dysfunction than non‑seroton...

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