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Index/Topics/STEP-1 Trial

STEP-1 Trial

The STEP-1 trial is mentioned as showing that participants regained about two-thirds of their prior weight loss within one year after stopping weekly semaglutide 2.4 mg.

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Jan 21, 2026

How quickly does weight typically return after stopping GLP‑1 therapy and what strategies exist to maintain weight loss?

commonly leads to clinically meaningful weight regain within months to a year, though individual trajectories vary; randomized trials show much of the lost weight returns within 6–12 months and meta-a...

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