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Index/Topics/STEP-10 Trial

STEP-10 Trial

The STEP-10 trial reported that more than 40% of lost weight returned within roughly 28 weeks of stopping semaglutide.

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Jan 21, 2026

How quickly does weight typically return after stopping GLP‑1 therapy and what strategies exist to maintain weight loss?

commonly leads to clinically meaningful weight regain within months to a year, though individual trajectories vary; randomized trials show much of the lost weight returns within 6–12 months and meta-a...

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