factually
Index/Topics/SURPASS Trials

SURPASS Trials

Randomized trials to evaluate the cardiovascular outcomes of tirzepatide.

Fact-Checks

2 results
Jan 16, 2026
Most Viewed

What are the long‑term cardiovascular outcomes associated with tirzepatide treatment?

Randomized-trial evidence to date indicates that tirzepatide does not increase major adverse cardiovascular events and has shown signals of cardiovascular benefit in specific populations: a pre‑specif...

Jan 22, 2026
Most Viewed

What are the cardiovascular outcomes of tirzepatide in real‑world observational studies beyond the first two years of treatment?

Real‑world observational studies of to date are short (median follow‑up well under two years) and heterogeneous, so there is effectively no robust real‑world evidence demonstrating cardiovascular outc...