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SYDNEY-2 Trial

The SYDNEY-2 randomized trial on alpha-lipoic acid for diabetic peripheral neuropathy.

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Jan 26, 2026
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What clinical evidence supports individual ingredients like alpha‑lipoic acid and acetyl‑L‑carnitine for peripheral neuropathy?

Randomized trials and meta-analyses provide the strongest clinical signal that can reduce pain and, in some studies, improve neurophysiological measures in peripheral neuropathy—most consistently in —...

Jan 20, 2026

What randomized clinical trials exist for blood‑sugar supplements containing chromium or alpha‑lipoic acid?

Randomized clinical trials of chromium and alpha‑lipoic acid (ALA) have been conducted for decades, but the literature is mixed: multiple RCTs and meta‑analyses exist showing small or inconsistent eff...