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Index/Topics/Synthetic opioid overdose trends

Synthetic opioid overdose trends

Synthetic opioid overdose deaths have declined and rebounded in recent years, with 72,776 deaths in 2023

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Jan 31, 2026

How do fentanyl overdose death totals compare to other opioid-related deaths annually since 2016?

From 2016 onward, deaths involving synthetic opioids—primarily illicitly manufactured —rose dramatically and overtook other opioid categories as the dominant cause of opioid-related mortality, with an...

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