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Tau-based approaches for Alzheimer's treatment

Tau-based approaches have shown promising biomarker changes and compelling animal data but limited clear cognitive benefit in humans. Clinical readouts from key trials are expected in the mid-2020s.

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Jan 29, 2026

How reliable are mouse models of Alzheimer’s at predicting human clinical outcomes, and what alternative preclinical systems exist?

remain indispensable for mechanistic insight and early safety testing in , but their track record at predicting successful human clinical outcomes is mixed: they reproduce specific neuropathologies an...

Jan 20, 2026

What potential treatments for Alzheimer's disease have been developed based on tau protein research?

A broad pipeline of tau-based approaches—small molecules that block aggregation or modify tau chemistry, immunotherapies that target extracellular tau, gene‑ and RNA‑based tactics that lower tau produ...