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Tau Burden and Amyloid-Lowering Therapies

The relationship between tau burden and the effectiveness of amyloid-lowering therapies in patients

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Feb 4, 2026

Have randomized trials tested whether changing sleep position alters amyloid or tau levels in humans?

No randomized trials have directly tested whether changing (for example, supine versus lateral) alters amyloid or tau levels in humans; the randomized human experiments reported in the scientific lite...

Feb 1, 2026

How do baseline tau PET levels modify the effect of amyloid‑lowering antibodies on clinical decline?

Baseline measured by strongly modifies how much clinical benefit patients derive from amyloid‑lowering antibodies: lower neocortical tau at baseline associates with larger slowing of cognitive decline...