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Toxicology and scene correlation to reach a mechanistic opinion
in humans most commonly produces gastrointestinal upset, circulatory instability and a range of neurological symptoms that can progress from lethargy and confusion to seizures, coma and rarely death; ...
Ivermectin’s pharmacokinetics are dominated by slow absorption, wide tissue distribution, low metabolic clearance and slow excretion, but those broad traits are heavily modulated by route and formulat...
Autopsy reports distinguish cardiopulmonary (cardiac) arrest from by combining scene information, cardiac and extracardiac gross and microscopic findings, and increasingly, —because the external and i...
Evidence from drug interaction databases, case reports, and prescribing references shows that ivermectin can alter —most notably with warfarin—producing rare but clinically meaningful increases in ble...
is a fast‑acting cellular asphyxiant: airborne concentrations in the low tens of ppm produce reversible effects and incapacitation thresholds, while concentrations in the low hundreds of ppm can be ra...
A small body of animal experiments, field trials, and case reports suggest can be associated with prolonged prothrombin time and reduced levels of –dependent clotting factors (II, VII, IX, X), but con...
Clinical and forensic laboratories identify ivermectin and its metabolites primarily with liquid chromatography coupled to mass spectrometry — ranging from targeted LC‑MS/MS for quantification to ultr...
There are no specific, documented drug–drug interactions between ivermectin and tamsulosin reported in the sources provided; major ivermectin interaction databases list many potential interacting drug...
Ivermectin overdose commonly produces gastrointestinal symptoms (nausea, vomiting, diarrhea), dizziness and other central nervous system effects (drowsiness, headache, tremor), and in more severe case...
Randomized-controlled evidence on whether ivermectin alters gut bacterial diversity or specific taxa remains limited but mixed: controlled human-trial data are emerging that report taxonomic shifts af...
Veterinary ivermectin formulations differ from human prescriptions primarily in concentration, formulation type, and inactive ingredients: animal products are made as high‑strength injectables, pour‑o...