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Weight Regain After Stopping GLP-1 Agonists

The topic is about the weight regain after stopping the treatment of GLP-1 agonists, including the analysis of randomized controlled trials and meta-analyses.

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Jan 18, 2026

What randomized evidence exists on sustained remission after GLP‑1 or GLP‑1/GIP agonist therapy withdrawal?

Randomized trial evidence and several recent systematic reviews show that clinically meaningful weight loss achieved with GLP‑1 and GLP‑1/GIP agonists is frequently lost after drug withdrawal—with mos...