Index/Organizations/LiverTox

LiverTox

The LiverTox database in NCBI Bookshelf

Fact-Checks

17 results
Nov 4, 2025
Most Viewed

Can green tea extract or EGCG cause liver toxicity and at what doses?

Green tea extract (GTE) and its major catechin, epigallocatechin gallate (EGCG), have been linked to , most often in the context of high-dose supplements rather than traditional brewed tea; regulatory...

Dec 20, 2025
Most Viewed

How common are gastrointestinal side effects from ivermectin in cancer patients?

Available evidence shows that gastrointestinal (GI) side effects — nausea, vomiting, diarrhea, abdominal pain — are known and relatively common adverse reactions to ivermectin in general use, but rigo...

Dec 5, 2025
Most Viewed

Can long-term bacopa use affect liver function, kidney function, or blood clotting?

Clinical and preclinical sources show no clear signal that Bacopa monnieri causes liver enzyme elevations or clinically apparent liver injury; LiverTox states “Bacopa has not been linked to liver enzy...

Jan 12, 2026

What are the most commonly reported side effects of moringa supplements like Rosabella at low (100–500 mg) doses?

Moringa supplements at typical low capsule doses (roughly 100–500 mg) are generally reported as well tolerated, with the most common complaints being mild gastrointestinal symptoms such as nausea, dia...

Dec 12, 2025

What are signs of L-glutamine overdose or adverse reactions?

Reported signs of L‑glutamine overdose or adverse reactions cluster around gastrointestinal upset (bloating, nausea, stomach cramps), allergic reactions (hives, rash, breathing difficulty), neuropsych...

Nov 4, 2025

How common is drug-induced liver injury from ivermectin in humans?

Drug‑induced liver injury (DILI) from ivermectin in humans is , primarily in case reports and pharmacovigilance datasets rather than large prospective studies. Available evidence shows occasional seri...

Dec 2, 2025

What are the potential side effects of taking high doses of Bacopa Monnieri?

High doses of Bacopa monnieri most commonly cause gastrointestinal problems—nausea, increased stool frequency, abdominal cramps and diarrhea—reported across clinical reviews and databases . Typical st...

Nov 7, 2025

What are documented case reports of ivermectin-induced liver injury and their publication dates?

Two well-documented, peer-reviewed case reports and several pharmacovigilance analyses document , with the earliest published case in 2006 and additional clinically serious reports appearing during th...

Dec 10, 2025

How do factors like age, liver disease, and drug interactions affect ivermectin toxicity thresholds?

Available reports show ivermectin is usually well tolerated at standard single-dose regimens but has documented, rare cases of clinically apparent liver injury and even fulminant liver failure after n...

Jan 2, 2026

What randomized controlled trials have tested Epimedium or icariin versus sildenafil or placebo for erectile dysfunction?

No randomized controlled trial (RCT) has directly compared purified icariin or single‑ingredient Epimedium products head‑to‑head with sildenafil in men with erectile dysfunction; human randomized tria...

Dec 20, 2025

What ingredients in over‑the‑counter weight‑loss supplements are most commonly linked to liver injury?

Over‑the‑counter weight‑loss supplements most commonly linked to clinically significant liver injury include green tea extract (GTE, especially EGCG), Garcinia cambogia (hydroxycitric acid), usnic aci...

Dec 16, 2025

Are there official guidelines for ivermectin use in patients with chronic liver disease?

There are no single, global "official guidelines" that specifically prescribe ivermectin use in people with chronic liver disease; major drug references and pharmacovigilance reports advise caution an...

Dec 16, 2025

How do patient factors (age, liver function, co-medications) modify adverse effects with different ivermectin schedules?

Age, baseline liver disease and interacting drugs change the risk profile of ivermectin mainly by increasing the chance of liver enzyme elevations, rare clinically apparent liver injury, and other sys...

Dec 4, 2025

Which specific ingredients in detox supplements are linked to liver injury in clinical studies?

Clinical reports and surveillance databases and reviews repeatedly link specific supplement ingredients to drug-induced liver injury (DILI): green tea extract, turmeric (high‑dose/curcumin), kava, bla...

Dec 2, 2025

What is the evidence for liver toxicity or hepatotoxicity from long-term bacopa monnieri use?

Major toxicology resources and animal studies find no convincing evidence that Bacopa monnieri causes liver injury: LiverTox assigns Bacopa a likelihood score "E" (unlikely cause of clinically apparen...

Nov 26, 2025

What ingredients are in Lipo Max and which ones pose liver or kidney risks?

Available reporting shows “Lipo Max” is not a single, uniform product: references in 2024–2025 describe multiple formulations and product categories — from liquid “Lipomax Drops” weight‑management sup...

Nov 16, 2025

What doses of Moringa oleifera caused adverse effects in clinical trials?

Clinical trials and human studies generally report Moringa oleifera as well tolerated at commonly used doses (for example, single whole‑leaf powder doses up to 50 g and repeated doses like 8 g/day for...